✦ LIBER ✦

Isoprenoid modification permits 2′,3′-cyclic nucleotide 3′-phosphodiesterase to bind to membranes

✍ Scribed by Dr. P. E. Braun; D. De Angelis; W. W. Shtybel; L. Bernier

Book ID: 102912909
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 672 KB
Volume: 30
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490300311

No coin nor oath required. For personal study only.

✦ Synopsis

The myelination-related enzyme 2' ,3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a relatively abundant protein in the CNS possesses the C-terminal isoprenylation consensus domain found in a small family that includes the rus oncoproteins and their relatives, some G-proteins, and nuclear lamins. We found that CNP, like these other proteins, is modified posttranslationally by an isoprenoid derived from meva-Ionic acid. It appears that only the smaller of the two CNP isoforms (CNP1) is isoprenylated, but similar modification of CNP2 cannot be excluded. Inhibition of isoprenoid synthesis by Lovastatin blocks the binding of newly synthesized CNP to cell membranes; binding is restored upon addition of mevalonate to the culture medium. This shows that isoprenylation is permissive for the well-known avid association of CNP with membranes.

📜 SIMILAR VOLUMES

Localization of 2′,3′-cyclic nucleotide

Localization of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in human erythrocyte membranes

✍ Charles E. Dreiling 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 611 KB

T cell response to 2′,3′-cyclic nucleoti

T cell response to 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) in multiple sclerosis patients

✍ P.A Muraro; M Kalbus; G Afshar; H.F McFarland; R Martin 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 166 KB

2′,3′-Cyclic nucleotide 3′-phosphodieste

2′,3′-Cyclic nucleotide 3′-phosphodiesterase: A novel RNA-binding protein that inhibits protein synthesis

✍ Michel Gravel; Francis Robert; Vicky Kottis; Imed-Eddine Gallouzi; Jerry Pelleti 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 617 KB

## Abstract 2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase (CNP) is one of the earliest myelin‐related proteins to be specifically expressed in differentiating oligodendrocytes (ODCs) in the central nervous system (CNS) and is implicated in myelin biogenesis. CNP possesses an in vitro enzymatic activ

Studies on the Wolfgram High Molecular W

Studies on the Wolfgram High Molecular Weight CNS Myelin Proteins: Relationship to 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase

✍ Terry Joe Sprinkle; Michael R. Wells; Fred A. Garver; Dennis B. Smith 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 870 KB

Evidence for the Association of 2′,3′-Cy

Evidence for the Association of 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase with Myelin-Related Membranes in Peripheral Nervous System

✍ Jean-Marie Matthieu; Elvira Costantino-Ceccarini; Michèle Bény; Jacqueline Reign 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 556 KB

ACTIVITY OF 2′,3′-CYCLIC-NUCLEOTIDE 3′-P

ACTIVITY OF 2′,3′-CYCLIC-NUCLEOTIDE 3′-PHOSPHODIESTERASE IN REGIONS OF RAT BRAIN DURING DEVELOPMENT: QUANTITATIVE RELATIONSHIP TO MYELIN BASIC PROTEIN

✍ T. J. Sprinkle; M. E. Zaruba; G. M. McKhann 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 441 KB