Isoniazid overdose treated with high-dose pyridoxine

✍ Scribed by Barry E. Yarbrough; Judy P. Wood

• Book ID: 104312553
• Publisher: Elsevier Science
• Year: 1983
• Tongue: English
• Weight: 347 KB
• Volume: 12
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(83)80514-9

✦ Synopsis

drug overdose, isoniazid; isoniazid, overdose; overdose, isoniazid, treated with pyridoxine; pyridoxine, for isoniazid overdose

Isoniazid Overdose Treated With High.Dose Pyridoxine

Large doses of pyridoxine recently have been shown to prevent the seizures and acidosis caused by ingestion of more than two to three grams of isoniazid. We present three cases of massive isoniazid ingestion, producing seizures and acidosis, that were treated successfully by administration of one gram of pyridoxine intravenously for each gram of isoniazid ingested. [Yarbrough BE, Wood JP: Isoniazid overdose treated with high-dose pyridoxine.