✦ LIBER ✦

Isoniazid-induced intolerance to ethanol in rabbit, guinea pig and rat

✍ Scribed by L. W. Whitehouse; C. J. Paul; B. H. Thomas

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 571 KB
Volume: 1
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510010503

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Isoniazid (50 or 100 mg kg^−l^ p.o.) inhibited the elimination of ethanol (0·5, 1·0, and 2·5 g kg^−l^ p.o.) from the plasma of rabbit, guinea pig, and rat. The effect of isoniazid, isonicotinic acid, N‐acetylisoniazid, N‐acetylhydrazine, N,N‐diacetylhydrazine, and hydrazine on the in vitro metabolism of alcohol by rabbit liver alcohol dehydrogenase was examined. Only isoniazid, hydrazine, and acetylisoniazid showed significant inhibitory activity with I~50~'s of 17·7, 1·25, and 0·78 mmol 1^−1^ respectively. Intolerance to ethanol following isoniazid treatment was attributed to isoniazid inhibition of liver alcohol dehydrogenase.

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