Isomerization of Propargylic Alcohols into α,β-Unsaturated Carbonyl Compounds Catalyzed by the Sixteen-Electron Allyl-Ruthenium(II) Complex [Ru(η3-2-C3H4Me)(CO)(dppf)][SbF6]

✍ Scribed by Victorio Cadierno; Sergio E. García-Garrido; José Gimeno

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 180 KB
• Volume: 348
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200505294

✦ Synopsis

Abstract

The 16‐e^−^ (η^3^‐allyl)‐ruthenium(II) complex [Ru(η^3^‐2‐C~3~H~4~Me)(CO)(dppf)][SbF~6~] is an efficient catalyst for the regioselective isomerization of terminal propargylic alcohols HCCCR^1^R^2^(OH) into α,β‐unsaturated aldehydes R^1^R^2^CCHCHO or ketones R^3^R^4^CC(R^1^)COMe (if R^2^=CHR^3^R^4^) under mild conditions. This complex has been also used as catalyst for the preparation of conjugated 1,3‐enynes via dehydration of propargylic alcohols.