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Isomerization and formulation stability of the vaccine adjuvant QS-21

✍ Scribed by Jeffrey L. Cleland; Charlotte R. Kensil; Amy Lim; Neil E. Jacobsen; Louisette Basa; Michael Spellman; Deborah A. Wheeler; Jia-Yan Wu; Michael F. Powell


Book ID
109388424
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
385 KB
Volume
85
Category
Article
ISSN
0022-3549

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Studies were performed to elucidate the mechanism of alum gel coagulation upon freezing and drying and its relationship to vaccine potency loss and to develop a novel freeze-drying process for the production of stable alum-adjuvanted vaccine formulations suitable for conventional needle injection an