Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling
β Scribed by Chen, Xiangzheng; Wu, Yangping; Jiang, Yangfu; Zhou, Yan; Wang, Yuxi; Yao, Yuqin; Yi, Cheng; Gou, Lantu; Yang, Jinliang
- Book ID
- 118778750
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 468 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0946-2716
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## Abstract We characterized the effects of a newly developed signal transducers and activators of transcription 3 (STAT3) inhibitor, LLL12 in multiple myeloma (MM) cells. LLL12 specifically inhibited STAT3 phosphorylation, nuclear localization, DNA binding activity, downβregulated STAT3 downstream
The evolutionarily conserved Ras/Raf/MEK/ERK pathway is thought to be essential for proliferation of eukaryotic cells. The human multiple myeloma (MM) cell line 8226 encodes an activated K-ras allele and proliferates without requirement for the main MM growth and survival factor IL-6. Surprisingly,