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Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells

✍ Scribed by Sarvesh Kumar; Amit Sharma; Babita Madan; Vandana Singhal; Balaram Ghosh


Book ID
113488208
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
817 KB
Volume
73
Category
Article
ISSN
0006-2952

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## Abstract In response to inflammation stimuli, tumor necrosis factor‐α (TNF‐α) induces expression of cell adhesion molecules (CAMs) in endothelial cells (ECs). Studies have suggested that the nuclear factor‐κB (NF‐κB) and the p38 MAP kinase (p38) signaling pathways play central roles in this proc