Isolierung von Streptothricin-resistenten Mutanten aus Escherichia coli K12, Stamm A19
✍ Scribed by L. Seidel; Ina Haupt
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 330 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0233-111X
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✦ Synopsis
Abstract
Mutants with various levels of resistance to streptothricin were isolated from Escherichia coli K12, strain A19 after mutagenesis with N‐methyl‐N'‐nitroso‐guanidine and ethylmethane‐sulfonate. Nourseothricin, a mixture of streptothricin F. and D was the selection agent. Spontaneous resistant mutants could not be found. The streptothricin‐resistant mutant E. coli A19 Stcr 2/2/1 shows cross‐resistance to some of the aminoglycoside antibiotics investigated, but no cross‐resistance to chloramphenicol and chlortetracyclin. These results indicate similar mechanisms of action of streptothricin and aminoglycoside antibiotics.