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Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp. HKI 0276

✍ Scribed by Dr Albrecht Berg; Pavel A. Grigoriev; Thomas Degenkolb; Torsten Neuhof; Albert Härtl; Brigitte Schlegel; Udo Gräfe

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
153 KB
Volume
9
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

Trichofumins A–D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

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