𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Isolation rearing of rats alters release of 5-hydroxytryptamine and dopamine in the frontal cortex: an in vivo electrochemical study

✍ Scribed by Francesco Crespi; Ian K. Wright; Claudia Möbius

Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
735 KB
Volume
88
Category
Article
ISSN
0014-4819

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of rearing hooded Lister rats either in groups of seven or singly on 5-hydroxytryptamine (5-HT) and dopamine (DA) release in the frontal cortex were investigated using in vivo voltammetry together with Nafion coated carbon fibre micro-electrodes. The selective detection of basal extracellular levels of 5-HT with this technique (Peak B) was confirmed with parallel experiments using intracranial microdialysis to measure 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in vivo. The DA voltammetric signal (Peak A) was observed in vivo only following pharmacological or electrical stimulation of DA release. Enhanced efflux of cortical DA and 5-HT in response to local application of KCl and that of 5-HT following parentelar fenfluramine were selectively detected by the association: differential pulse voltammetry (DPV)-Nafion coated microbiosensors, supporting the capability of this electrochemical method to selectively monitor release of these amine neurotransmitters in vivo and in situ. The locomotor behaviour data indicated that isolation rearing resulted in augmented locomotor activity in a novel environment. In addition, the in vivo voltammetric results showed that following KCl or fenfluramine treatment cortical 5-HT release is prolonged while that of DA is increased in rats reared in isolation when compared with socially reared rats. This imbalance between extracellular levels of DA and 5-HT recorded in the frontal cortex of rats exposed to isolated housing conditions may contribute to the behavioural differences reported between isolation and group reared rats.

📜 SIMILAR VOLUMES

Acute and chronic administration of the
Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study
✍ Yoshio Minabe; Kiyoshi Matsuno; Charles R. Ashby Jr. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

In this study, we examined the effect of the acute and repeated administration of the selective sigma () 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on the number and firing pattern of spontaneously active dopamine (DA) neurons in substantia ni

The characterization of the effect of lo
The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: An in vivo microdialysis study
✍ Kenichi Kurata; Charles R. Ashby Jr.; Robert Oberlender; Yasuyuki Tanii; Masayos 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 987 KB

In this study, we examined the effect of n-methylquipazine (NMQ), which is a putative 5-hydr~xytryptamine~ (5-HT3) receptor agonist, on the extracellular concentrations of dopamine (DA) and one of its metabolites, dihydroxyphenylacetic acid (DOPAC), in the anterior medial prefrontal cortex (AmPFc) o