ISOLATION REARING IN RATS WITH A NEONATAL VENTRAL HIPPOCAMPAL LESION: A MODEL OF ENVIRONMENTAL EFFECTS IN SCHIZOPHRENIA PATHOPHYSIOLOGY
β Scribed by Gwendolyn G. Calhoon; Carrie E. John; Patricio O'Donnell
- Book ID
- 119364934
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 63 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0920-9964
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## Abstract Rat with excitotoxic neonatal ventral hippocampal lesions (NVHL rats) is considered as a heuristic neurodevelopmental model for studying schizophrenia. Extensive study of this model is limited by the lack of clear validity criteria of such lesions and because ascertaining of the lesions
A neurodevelopmental model of schizophrenia in rats has recently been proposed employing neonatal hippocampal lesions. The present study further characterizes this model by investigating the long-term effects of neonatal hippocampal lesions up to 100 days after birth, in male rats as well as female