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Isolation of zidovudine resistant from AIDS patients

โœ Scribed by LEWIN, C; WATT, B; PATON, R; AMYES, S

Book ID
122253214
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
137 KB
Volume
70
Category
Article
ISSN
0378-1097

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Replication of HIV introduces errors into the genome which are responsible for conferring a growth advantage over wildtype virus when drugs such as zidovudine (ZDV) exert a selective pressure. The molecular basis for HIV-1 resistance to ZDV has been mapped to codons 41, 67, 70, 215 and 219 of the re