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Isolation of the bovine uridine monophosphate synthase gene to identify the molecular basis of DUMPS in cattle

✍ Scribed by B. Harlizius; S. Schöber; I. Tammenm; D. Simon


Book ID
115144087
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
489 KB
Volume
113
Category
Article
ISSN
0931-2668

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Uridine monophosphate synthase (UMPS) catalyzes the final two steps of de novo pyrimidine synthesis, converting orotic acid to uridine 5' monophosphate. In Holstein and Red Holstein cattle, deficiency of UMPS (DUMPS) is inherited as a monogenic autosomal recessive trait. Heterozygous animals are phe