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Isolation of parthenolide by droplet counter-current chromatography

✍ Scribed by Á. Kéry; Gy. Turiák; P. Tétényi


Book ID
104144673
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
339 KB
Volume
446
Category
Article
ISSN
1873-3778

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✦ Synopsis


The advantages and potential of droplet counter-current chromatography in the semi-preparative-and preparative-scale isolation of parthenolide and related sesquiterpene lactones was studied. Two systems, benzene-chloroform-methanol-water and chloroform-trichloroethylene-acetonitrile-methanol-water, were found to be suitable for the isolation of sesquiterpene lactones from Asteraceae plants.


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This paper reports the separation of the indole alkaloids from the benzene extract of the root barks of Tabernaemontana hilariana (Apocynaceae). The crude alkaloid fraction was fractionated by droplet counter-current chromatography using a low polarity mixture (hexane:ethyl acetate:ethanol:water). N