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Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase

✍ Scribed by Renhua Huang; Pete Fang; Brian K. Kay


Book ID
119331118
Publisher
Elsevier
Year
2012
Tongue
English
Weight
914 KB
Volume
29
Category
Article
ISSN
1871-6784

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SH3 domain of Bruton's tyrosine kinase c
✍ Himatkumar V. Patel; Shiou-Ru Tzeng; Chen-Yee Liao; Shi-Han Chen; Jya-Wei Cheng πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 115 KB

X-linked agammaglobulinemia (XLA), an inherited disease, is caused by mutations in the Bruton's tyrosine kinase (BTK). The absence of functional BTK leads to failure of B-cell differentiation; this incapacitates antibody production in XLA patients, who suffer from recurrent, sometimes lethal, bacter