✦ LIBER ✦

Isolation of leishmanicidal triterpenes and lignans from the Amazonian liana Doliocarpus dentatus (dilleniaceae)

✍ Scribed by Michel Sauvain; Nicole Kunesch; Jacques Poisson; Jean-Charles Gantier; Philippe Gayral; Jean-Pierre Dedet

Book ID: 101285455
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 349 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199602)10:1<1::aid-ptr757>3.0.co;2-a

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✦ Synopsis

The in uitro antileishmanial activity of triterpenes and lignans of an Amazonian medicinal plant, Doliocarpus dentutus (Aublet) Standley, is reported for the first time against amastigotes of Leishmania amazonensis. Terpenes, for example, betulinic acid, betulin and betulinaldehyde were isolated by bioassay-linked extraction. The lignans were characterized as (+) pinoresinol, (+) medioresinol and (-) lirioresinol B.