๐”– Bobbio Scriptorium
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Isolation of infectious EB virus from the epithelial tumour cells of nasopharyngeal carcinoma

โœ Scribed by P. A. Trumper; M. A. Epstein; B. C. Giovanella; S. Finerty

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
880 KB
Volume
20
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Abstract

Evidence of herpesvirus replication has been found by light and electron microscopy in the malignant epithelial cells of two out of six nasoโ€pharyngeal carcinomas (NPC) examined directly after growth in nude mice to eliminate nonโ€malignant infiltrating cells. The agent has been identified as EB virus by immunofluorescence tests for EB virus capsid antigen, and has been shown to be biologically active by its ability to infect and transform foetal cord blood lymphocytes. Lymphoโ€blastoid cell lines which express the EB virus nuclear antigen have been established from the transformed foetal lymphocytes, and thus carry the first isolate of the virus from the actual epithelial tumour cells of NPC, in a form suitable for further investigation. The results are discussed in terms of the relationship of EB virus to NPC epithelial cells.

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