Isolation of IgG1-secreting switch variants from IgM hybridomas produced after in vitro immunization

Rheumatoid factors and secondary immune

Rheumatoid factors and secondary immune responses in the mouse I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens

✍ Jacques Van Snick; Pierre Coulie 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 505 KB

The involvement of rheumatoid factor (RF)-secreting cells in normal immune responses was examined by screening hybridomas derived from 129/Sv mice during primary and secondary immune responses against foreign proteins. No RF-secreting cells were detected during primary responses, but up to 10% of th