Isolation of glycosaminoglycans from basement membranes of brain microvessels
โ Scribed by Schmidley, James W.; Blue, Patricia
- Book ID
- 122546012
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 833 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0361-9230
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To study the transport system of propranolol (PL), a basic drug, in the blood-brain barrier, the uptake of PL into isolated bovine brain microvessels was investigated. The uptake of PL was a concentrative one via saturable process (Km = 42.5 microM) that was decreased by hypothermia (Q10 = 2.2), but