## Communicated by Riccardo Fodde The 22q11.2 microdeletion syndrome is the most frequent microdeletion syndrome in humans, yet its genetic basis is complex and is still not fully understood. Most patients harbor a 3-Mb deletion (typically deleted region [TDR]), but occasionally patients with atypi
Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2
β Scribed by Jun-Ying Zhou; Benjamin Fogelgren; Zhili Wang; Bruce A. Roe; Jaclyn A. Biegel
- Book ID
- 117523904
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 350 KB
- Volume
- 241
- Category
- Article
- ISSN
- 0378-1119
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Rhabdoid tumors of the kidney are highly malignant neoplasms that occur primarily within the first 3 years of life. Although they are regarded as distinct from Wilms' tumors, their pathogenesis remains unclear. Whereas most cytogenetic studies of these tumors have revealed normal karyotypes, a few r
Malignant rhabdoid tumors are rare and aggressive neoplasms of childhood, occurring in the kidney or in various extrarenal locations. Most cytogenetic studies of these tumors have shown the frequent involvement of chromosome 22, including translocations and/or deletions, with a critical region for a