Isolation of EGF-dependent transforming growth factor (TGFβ-like) activity from culture medium conditioned by fetal rat calvariae

Plasminogen-dependent activation of late

Plasminogen-dependent activation of latent transforming growth factor beta (TGFβ) by growing cultures of osteoblast-like cells

✍ John A. Yee; Lin Yan; Juan C. Dominguez; Elizabeth H. Allan; T. John Martin 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 801 KB

## Abstract Osteoblasts secrete transforming growth factor beta (TGFβ) as a biologically inert, latent complex that must be dissociated before the growth factor can exert its effects. We have examined the production and proteolytic activation of latent TGFβ (LTGFβ) by clonal UMR 106‐01 rat osteosar