✦ LIBER ✦
Isolation of drugs from autopsy material by XAD-2 adsorption-elution technique a routine procedure
✍ Scribed by Maciej Bogusz; Jolanta Gierz; Józefa Białka
- Book ID
- 104713821
- Publisher
- Springer-Verlag
- Year
- 1978
- Tongue
- English
- Weight
- 469 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0340-5761
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✦ Synopsis
The method of adsorption of drugs on Amberlite XAD-2 resin, followed by differential elution was under study during 1 1/2 year of routine use. The method allows a separation of acidic and basic drugs and--due to acid hydrolysis step before adsorption--assures better recovery of conjugated and protein-bound drugs. The amounts of various drugs, found in autopsy cases by the XAD-2 method were usually higher than those found by solvent extraction. The method applied requires 20 g of sample (biofluid or tissue) for general toxicological analysis.