Isolation of (−)-cyatha-3,12-diene, a common biosynthetic intermediate of cyathane diterpenoids, from an erinacine-producing basidiomycete, Hericium erinaceum, and its formation in a cell-free system
✍ Scribed by Hiromichi Kenmoku; Nobuo Kato; Masaki Shimada; Mineko Omoto; Akira Mori; Wataru Mitsuhashi; Takeshi Sassa
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 80 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Cyatha-3,12-diene, a diterpene hydrocarbon having a 5-6-7-membered tricyclic skeleton, has been isolated for the first time from an erinacine-producing basidiomycete, Hericium erinaceum YB4-6237. This hydrocarbon had been formulated by Ayer et al. as a common biosynthetic intermediate of cyathane diterpenoids. Its stereo-structure, including the absolute configuration, has been unambiguously confirmed by its semi-synthesis from erinacine P, and its cell-free conversion from all-trans-geranylgeranyl diphosphate was demonstrated.