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Isolation of Chinese hamster ovary cells with reduced poly(ADP-ribose) polymerase activity

✍ Scribed by Renate A. MacLaren; Marc V. Witmer; Edwin Richardson; Thomas D. Stamato

Book ID
113193756
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
818 KB
Volume
231
Category
Article
ISSN
0027-5107

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## Abstract Poly(ADP‐ribose)polymerase (PARP‐1), a nuclear enzyme activated by DNA strand breaks, is involved in DNA repair, aging, inflammation, and neoplastic transformation. In diabetes, reactive oxygen and nitrogen species occurring in response to hyperglycemia cause DNA damages and PARP‐1 acti