Isolation of CEA-like material from urinary bladder carcinoma

✍ Scribed by Zimmerman, Rolf ;Hammarstr�m, Sten

• Book ID: 104689956
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 355 KB
• Volume: 6
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00262621

✦ Synopsis

Carcinoembryonic antigen (CEA)-like material from urinary bladder carcinoma was purified and compared with the immunological and physico-chemical properties of CEA isolated from colon cancer. After immunoadsorbent purification, the final step in a purification procedure similar to that adopted for colon cancer CEA, two main molecular species were identified: 1) Material identical with colon cancer CEA with respect to molecular size, PCA solubility, ability to bind to Con A, and most important the ability to bind to specific monkey anti-CEA serum. 2) Material with the same chromatographic and immunological properties as NCA.