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Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1)

✍ Scribed by Judit Erchegyi; Abba J. Kastin; James E. Zadina

Book ID: 119142677
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 796 KB
Volume: 13
Category: Article
ISSN: 0196-9781
DOI: 10.1016/0196-9781(92)90165-y

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Endogenous peptide Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport system-1

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Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH,) is a recently isolated peptide that belongs to a larger family that includes Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH,) and MIF-1 (Pro-Leu-Gly-NH,). Despite similarities in structure, Tyr-MIF-1 and MIF-1 can act differently in behavioral, blood-brain barrier (BBB) transport, a