Isolation of a multifunctional complex containing the first three enzymes of pyrimidine biosynthesis in Drosophila melanogaster
โ Scribed by B. Jarry
- Book ID
- 115906807
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- English
- Weight
- 416 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0014-5793
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๐ SIMILAR VOLUMES
Some metabolic pathways are nearly ubiquitous among organisms: the genes encoding the enzymes for such pathways must therefore be ancient and essential. De novo pyrimidine biosynthesis is an example of one such metabolic pathway. In aninials a single protein called CADI-carries the first three steps
The rudimentary locus (r; X--55.3) of Drosophila melanogaster is shown to contain the structural sequences for the enzymes CPSase, ATCase and DHOase. The enzyme concentration in adult flies is correlated with the number of r+ copies in the genome. The expression of the locus follows the rules of the