cDNA libraries have been constructed in plasmid (pBR322) and bacteriophage (XgtlO) vectors with poly (A+) RNA isolated from the nonfusing mouse muscle cel! line BC3H-1. The libraries were screened with a restriction fragment derived from a genomic clone coding for a human acetylcholine receptor y su
✦ LIBER ✦
Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit
✍ Scribed by Boulter, Jim; Evans, Karen; Goldman, Dan; Martin, Gary; Treco, Doug; Heinemann, Steve; Patrick, Jim
- Book ID
- 109742516
- Publisher
- Nature Publishing Group
- Year
- 1986
- Tongue
- English
- Weight
- 884 KB
- Volume
- 319
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/319368a0
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The ␣4 subunit gene of the neuronal nicotinic acetylcholine receptor (CHRNA4) has recently been identified as the first gene underlying an idiopathic partial epilepsy syndrome in human, autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE). CHRNA4 is located in the candidate region for benign