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Isolation, identification, and synthesis of the major sulpiride metabolite in primates

✍ Scribed by J. J. Brennan; A. R. Imondi; D. G. Westmoreland; M. J. Williamson

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 528 KB
Volume: 71
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600711104

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✦ Synopsis

The major metabolite of sulpiride, N-[( 1-ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-2-anisamide (I), in the monkey is N-[(lethyl-5-oxo-2-pyrrolidinyl)methyl]-5-sulfamoyl-2-anisamide (11). It is also a metabolite in other laboratory animal species and possibly at very low levels in humans. Treatment of the urine from a monkey dosed orally with I4C-I by dry column chromatography and high-pressure liquid chromatography (HPLC) produced the major metabolite in pure form. Characterization of the purified 14C-radiolabeled metabolite by proton NMR, TLC, HPLC, and chemical ionization mass spectroscopy, along with subsequent comparison of a synthetically prepared sample, gave unequivocal structural confirmation.

Keyphrases CI Sulpiride-isolation, identification, and synthesis of major metabolites, monkeys High-pressure liquid chromatography-analysis, major sulpiride metabolites, monkeys 0 Metabolitessulpiride, isolation, identification, and synthesis, monkeys Sulpiride (I) is a structurally unique antipsychotic drug. Studies utilizing 14C-labeled I indicated that, while this

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