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Isolation, identification and determination of sulfadiazine and its hydroxy metabolites and conjugates from man and Rhesus monkey by high-performance liquid chromatography

โœ Scribed by T.B. Vree; E.Schoondermark-van de Ven; C.P.W.G.M. Verwey-van Wissen; A.M. Baars; A. Swolfs; P.M. van Galen; H. Amatdjais-Groenen

Publisher
Elsevier Science
Year
1995
Weight
781 KB
Volume
670
Category
Article
ISSN
0378-4347

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Encainide (ENC) and its metabolites O-demethylencainide (ODE), 3-methoxy-O-demethylencainide (MODE), N-demethylencainide (NDE) and bis-N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a mu Porasil column with ethanol-water-methanesulphonic acid as mob