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Isolation from human gastric juice of an antigen closely related to the carcinoembryonic antigen

✍ Scribed by Matti Vuento; Eva Engvall; Markku Seppälä; Erkki Ruoslahti

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
489 KB
Volume
18
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A carcinoembryonic antigen‐like antigen(s) (CELIA) was isolated from normal human gastric juice by immunoadsorbents and gel chromatography. The isolated CELIA reacted identically to CEA in immunodiffusion tests against anti‐CEA and anti‐CELIA. Other experiments suggested subtle differences between CELIA and CEA. Two out of six CELIA preparations tested in immunodiffusion did not react in a completely identical manner with CEA. In gel filtration, CELIA eluted slightly after CEA. Absorption of anti‐CEA with CELIA resulted in antisera with greatly reduced reactivity to CELIA, but retained anti‐CEA activity. Such antisera may be helpful in attempts to increase the cancer specificity of the CEA test.

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