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Isolation, characterization and degradation of nogalamycin

✍ Scribed by P.F. Wiley; F.A. MacKellar; E.L. Caron; R.B. Kelly

Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
340 KB
Volume
9
Category
Article
ISSN
0040-4039

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✦ Synopsis

Nogalamycin, an antibiotic highly active against gram-positive bacteria and KEI cells, in vitro (l), was isolated in a crude state by extraction of a filtered fermentation -broth with ethyl acetate. Further purification was achieved by repeated extraction from ethyl acetate with dilute acid followed by neutralization and reextraction with ethyl acetate. The final steps in purification were chromatography on silica gel in chloroformmethanol (9:l) and recrystallization from methanol. Pure nogalamycin (I) is an orangered solid, m.p. 195-156Β° dec.; CCXI~~' + 479" (CHCla); pKa 7.45 (60% EtOH); AEtoH236 max

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