Isolation and uptake characteristics of adenovirus transformed cell revertants resistant to the antiproliferative effects of methylglyoxal bis(guanylhydrazone)

Genetic characterization of adenovirus t

Genetic characterization of adenovirus transformed cell revertants resistant to methylglyoxal bis(guanylhydrazone): Evidence for the involvement of three genetic loci

✍ Nezha Alami; Arvind Chopra; Jean-Paul Thirion 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 784 KB

Five new independent rat somatic cell mutants resistant to the antileukemic drug methylglyoxal bis(guany1hydrazone) (MGBG) were isolated after mutagen treatmen[. The mutants were 7to 10-fold more resistant to MCBG than were the parental wild-type cells. When the MGBG-resistant (MGK) mutants were exp