Total synthesis of natural cis-3-hydroxy
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Navnath B. Kalamkar; Vijay M. Kasture; Dilip D. Dhavale
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Article
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2010
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Elsevier Science
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French
โ 265 KB
Synthesis of cis-3-hydroxy-L-proline from D-glucose is reported. The methodology involves conversion of D-glucose into N-benzyloxycarbonyl-c-alkenyl amine which on 5-endo-trig-aminomercuration gave the pyrrolidine ring skeleton with sugar appendage in 25% yield. Alternatively, N-benzyloxycarbonyl-c-