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Isolation and Structure of Biologically Active Gangliosides from the Sea Cucumber Holothuria pervicax

✍ Scribed by Koji Yamada; Yasuo Harada; Yoshiteru Nagaregawa; Tomofumi Miyamoto; Ryuichi Isobe; Ryuichi Higuchi


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
383 KB
Volume
1998
Category
Article
ISSN
1434-193X

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✦ Synopsis


Three ganglioside molecular species, HPG-8, HPG-3, and species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2Ǟ4-HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic pheochromocytoma cell line, PC-12 cells. evidence. They represent new ganglioside molecular


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