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Isolation and structure determination of piptocarphins A-F, cytotoxic germacranolide lactones from Piptocarpha chontalensis

✍ Scribed by Cowall, Patricia; Cassady, John M.; Chang, Ching-Jer; Kozlowski, John F.


Book ID
120597190
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
1017 KB
Volume
46
Category
Article
ISSN
0022-3263

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Apicularen A and B, Cytotoxic 10-Membere
✍ Rolf Jansen; Brigitte Kunze; Hans Reichenbach; Gerhard HΓΆfle πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 303 KB πŸ‘ 2 views

A novel highly cytotoxic metabolite, apicularen A (1), was isolated in a screening of the myxobacterial genus Chondromyces. The structure of 1 is characterized by a salicylic acid residue as part of a 10-membered lactone, which bears an acylenamine side chain. Compound 1 is an inhibitor of the proli