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Isolation and semi-synthesis of a bioactive taxane from Taxus canadensis

✍ Scribed by Lolita Ora Zamir; Maria Elena Nedea; Zhen-Hua Zhou; Gaétan Caron; Françoise Sauriol; Orval Mamer

Book ID
103341549
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
223 KB
Volume
41
Category
Article
ISSN
0031-9422

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A taxane with an amino-side chain on C-5 was identified for the first time from rooted cuttings of the Canadian yew, Taxus canadensis. The structure was characterized as 7b,9a,10b,13a-tetraacetoxy-5a-[3 0 -(N-formyl-N-methylamino)-3 0 -phenylpropanoyl]oxytaxa-4(20),12-diene (1) on the basis of 1D-,