Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients
โ Scribed by Sonali Ghosh; Putul Maity
- Publisher
- Springer Netherlands
- Year
- 2004
- Tongue
- English
- Weight
- 400 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1219-4956
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## Abstract Angiogenesis, the formation of new blood vessels, is controlled by a balance between positive and negative endothelial regulatory factors. Soluble vascular endothelial growth factor receptorโ1 (sVEGFR1), a naturally occurring soluble form of VEGFR1, is a negative counterpart of the vasc
Ascitic fluid from women with advanced ovarian carcinomas was shown to contain factor(s) which inhibit(s) T lymphocyte mitogenesis. The factor(s) was (were) demonstrated to be associated with the infiltrating macrophages. The inhibition was reversible and inhibited mitogenesis at some late event in
## Abstract ## BACKGROUND The vascular endothelial growth factor (VEGF) family and VEGF receptors (VEGFR) play an essential role in the angiogenesis of both pathologic and nonpathologic conditions. However, the prognostic significance of VEGF and VEGFR expression in ovarian carcinoma is unclear.