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Isolation and primary culture of human proximal renal tubular epithelial cells: Application to the study of cocaine-induced nephrotoxicity

✍ Scribed by M.J. Valente; P. Guedes De Pinho; R. Henrique; F. Carvalho; M.L. Bastos; M. Carvalho

Book ID: 116923100
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 79 KB
Volume: 196
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2010.03.496

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## Abstract Inflammation induces the NF‐κB dependent protein A20 in human renal proximal tubular epithelial cells (RPTEC), which secondarily contains inflammation by shutting down NF‐κB activation. We surmised that inducing A20 without engaging the pro‐inflammatory arm of NF‐κB could improve outcom