Isolation and physicochemical characterisation of the DNA from normal human skin and psoriatic scales
✍ Scribed by Günter Teimer; Gisela Ramb; Gottfried Leonhardi
- Publisher
- Springer-Verlag
- Year
- 1976
- Tongue
- English
- Weight
- 294 KB
- Volume
- 256
- Category
- Article
- ISSN
- 0340-3696
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DNA-binding proteins (DBP) of normal human dermis, epidermis, horny layer and psoriatic scales represent a tissue-specific group of mostly nuclear nonhistone proteins. To analyse their function, the different DBP fractions were examined concerning the presence of DNase, DNA-polymerase and RNA-polyme
The composition of DNA-binding proteins (DBP) was shown to be tissue-specific and to vary at different stages of gene expression. As the accelerated epidermopoesis in psoriasis indicates changed gene activities, DBP of psoriatic scales were compared with those of normal human epidermis, dermis and h