Isolation and partial synthesis of 3(R)- and 3(S)-deoxypumiloside; structural revision of the key metabolite from the camptothecin producing plant, Ophiorrhiza pumila

✍ Scribed by Mariko Kitajima; Seiji Masumoto; Hiromitsu Takayama; Norio Aimi

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 225 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00858-7

✦ Synopsis

Both the C-3 epimeric pair of 3(R)-and 3(S)-deoxypumiloside were found in Ophiorrhiza pumila (Rubiaceae), a source plant of camptothecinoid metabolites. These structures were confirmed by spectroscopic analysis and partial stereoselective syntheses. The configuration at C-3 of the previously reported "deoxypumiloside" is revised to 3(R) from 3(S).