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Isolation and in vitro expansion of human colonic stem cells

✍ Scribed by Jung, Peter; Sato, Toshiro; Merlos-Suárez, Anna; Barriga, Francisco M; Iglesias, Mar; Rossell, David; Auer, Herbert; Gallardo, Mercedes; Blasco, Maria A; Sancho, Elena

Book ID
111883674
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
660 KB
Volume
17
Category
Article
ISSN
1078-8956

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In general, it is presumed that colonic epithelial stem cells are the principal cell type at risk of incurring the series of somatic mutations leading to carcinoma, since all other epithelial cell types are short-lived. Mutant stem cell clonal expansion increases the risk for subsequent mutations an