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Isolation and identification of the glucuronide conjugate of 2-hydroxydesipramine by preparative liquid chromatography

✍ Scribed by Raymond F. Suckow; Thomas B. Cooper

Book ID
103803574
Publisher
Elsevier Science
Year
1988
Weight
578 KB
Volume
427
Category
Article
ISSN
0378-4347

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The three 2-mercaptoethanol (ME) thioether conjugates of 2-hydroxyacetanilide (2HAA) are detected and identified using liquid chromatography/electrochemistry (LC/EC). The conjugates are produced either by incubations of 2HAA with liver microsomes in the presence of NADPH and ME or by chemically oxid