Isolation and identification of metabolites of ofloxacin in rats, dogs and monkeys
β Scribed by Sudo, Kenichi; Okazaki, Osamu; Tsumura, Mitsuyoshi; Tachizawa, Haruo
- Book ID
- 120767722
- Publisher
- Informa plc
- Year
- 1986
- Tongue
- English
- Weight
- 466 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0049-8254
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π SIMILAR VOLUMES
The urine collected from three dogs for 24 hr. after oral administration of but~olol-'~C contained 61.2% of the administered radioactivity. An acidic metabolite, representing 16% of the urinary IrC, was purified by ether extraction and preparative TLC. The methyl ester of the metabolite was prepared
The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and