Isolation and identification of free amino acids as crystalline N-t-butyloxycarbonyl, O-phenacyl derivatives

One pot synthesis and conformation of N-

One pot synthesis and conformation of N-t-butyloxycarbonyl, O-Phenacyl derivatives of proline and other secondary amino acids

✍ John Hondrelis; Greg Lonergan; Stavros Voliotis; John Matsoukas 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 673 KB

Proline, 4-hydroxyproline, azetidine-2-carboxylic acid, pipecolic acid and proline containing dipeptides were converted to N-t-butyloxycarbonyl, 0-phenacyl derivatives in a one pot synthesis. 'H-and 13C-NMR spectroscopy of certain derivatives (Boc-Pro-PE, Boc-4Hyp-PE, Boc-Pro-4BrPE and Boc-Pip-PE) i