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Isolation and identification of a novel microorganism producing the immunosuppressant tacrolimus

โœ Scribed by Hyung Soo Kim; Young In Park


Book ID
118729380
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
360 KB
Volume
105
Category
Article
ISSN
1389-1723

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Pestalotia heterocornis was isolated from soil collected in yew forest and was shown to produce paclitaxel in semisynthetic liquid media. The presence of paclitaxel in the fungal extract was confirmed by FAB mass spectrometry and NMR spectroscopy. The maximum yield of paclitaxel was 31 ยตg per liter.