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Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene

✍ Scribed by Yonehiro Kanemura; Shoju Hiraga; Norio Arita; Takanori Ohnishi; Shuichi Izumoto; Kanji Mori; Hirotaka Matsumura; Mami Yamasaki; Shinji Fushiki; Toshiki Yoshimine


Book ID
117110253
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
646 KB
Volume
442
Category
Article
ISSN
0014-5793

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The human homologue of Drosophila patched (PTCH), located at chromosome 9q22.3, was recently identified as a candidate tumor suppressor gene for familial and sporadic basal cell carcinomas. Squamous cell carcinomas (SCCs) of the skin display allelic loss in this chromosomal region, which, in additio