Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the ϰ-Opioid Receptor.

Isolation and Chemical Modification of C

Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the κ-Opioid Receptor

✍ Yiqiang Li; Stephen M. Husbands; Mary F. Mahon; John R. Traynor; Michael G. Rowa 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB

## Abstract The clerodane diterpenoid salvinorin A (**1**), the main active component of the psychotropic herb __Salvia divinorum__, has been reported to be a potent agonist at the __κ__‐opioid receptor. Computer modeling suggested that splendidin (**2**) from __S. splendens__, as well as related c