The near-UV-induced photoreaction of the bifunctional 8-methoxypsoralen (8-MOP) with 2'-deoxyadenosine (dAdo) was investigated in the dry state. Four main monoadducts of 8-MOP to 2'-deoxyadenosine were separated by high performance liquid chromatography and subsequently characterized by soft ionizat
โฆ LIBER โฆ
Isolation and Characterization of Two Furan-side Photoadducts of 7-Methylpyrido[3,4-c] Psoralen to the Sugar Moiety of 2-Deoxyadenosine
โ Scribed by Lucienne Voituriez; Jean Cadet
- Book ID
- 111412631
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 687 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0031-8655
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When analysing the repair of psoralen plus UVA-induced photoadducts in DNA, it must be realized that, in most cases, different isomers are formed. The monofunctional psoralen derivative 7-methylpyrido(3,4-c)psoralen (MePyPs) is known for its high antiproliferative activity at the cellular level and