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Isolation and characterization of thioguanine resistant human promyelocytic leukemia cells

✍ Scribed by A.J. Bodner; S. Tsai; R.C. Ting; S.J. Collins; R.C. Gallo


Book ID
113237986
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
300 KB
Volume
4
Category
Article
ISSN
0145-2126

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A mutant human lymphoblastoid cell line, Raji-TG, resistant to 10~zg 6-thioguanine (TG)/ml was produced from wild-type cells after exposure to ethylmethane sulfonate. The Raji-TG cells showed their failure to incorporate 3H-hypoxanthine, only 2% as much hypoxanthine guanine phosphoribosyl transferas